David Mott has served as Chair of our Board of Directors since July 2012. Mr. Mott is a private investor through Mott Family Capital. From September 2008 until his retirement in February 2020, Mr. Mott served as a general partner of New Enterprise Associates, an investment firm focused on venture capital and growth equity investments, where he led the healthcare investing practice. Mr. Mott has served on the boards of directors of Adaptimmune since September 2014 and as chair thereof since January 2017; of Ardelyx, Inc., a biopharmaceutical company, since March 2009 and as chair thereof since March 2014; and of Novavax, Inc., a biotechnology company, since June 2020. He previously served as a director of Imara, Inc., a biotechnology company, from January 2016 and as chair of the board of directors from April 2016 until the reverse merger between Imara, Inc. and Enliven Therapeutics, Inc. in February 2023; of Epizyme, Inc., a biopharmaceutical company, from December 2009 and as chair of the board of directors from April 2016 until its acquisition by Ipsen Pharma SAS in August 2022; as a director of Nightstar Therapeutics plc, a gene therapy company, from August 2015 until its acquisition by Biogen Inc. in June 2019; and as a director of TESARO from May 2010 and as chair of the board of directors from July 2011 until its acquisition by GlaxoSmithKline in January 2019. Mr. Mott received a B.A. in economics and government from Dartmouth College.

Lawrence M. Alleva has served as a member of our Board of Directors since September 2017. Prior to his retirement in June 2010, Mr. Alleva was employed by PricewaterhouseCoopers LLP for 39 years, including 28 years as a partner. Mr. Alleva served clients primarily in the technology sector, as well as pharmaceutical and biotechnology companies. Additionally, he served in a variety of office and regional practice leadership roles, most recently as ethics and compliance leader (assurance) for PwC from 2006 until his retirement. Mr. Alleva is a Certified Public Accountant (inactive).

Mr. Alleva received a Bachelor of Science degree in accounting from Ithaca College and attended the Columbia University Executive MBA (non-degree) Program. Mr. Alleva also serves as a director for Bright Horizons Family Solutions Inc., Galera Therapeutics Inc. and Adaptimmune Therapeutics plc. He previously served as a director of TESARO, Inc., Mirna Therapeutics, Inc., and GlobalLogic, Inc., and chaired the audit committee for each of those companies.

Willard H. Dere, M.D., has served as a member of our Board of Directors since March 2018. Dr. Dere has served as Professor Emeritus of Internal Medicine at the University of Utah and an advisor to Angitia Biopharmaceuticals, a biopharmaceutical company, since June 2022. In June 2022, Dr. Dere retired from the Utah Health Services Center, where he had served as Professor of Internal Medicine, B. Lue and Hope S. Bettilyon Presidential Endowed Chair in Internal Medicine for Diabetes Research, Co-Director of the Utah Clinical and Translational Science Institute and Co-Director of the Center for Genomic Medicine since June 2014 and as Associate Vice President for Research since July 2019. Dr. Dere has served on the boards of directors of BioMarin Pharmaceutical Inc., a biopharmaceutical company, since July 2016 and of Seres Therapeutics, Inc., a biotechnology company, since July 2017. He previously served as a director of Radius Health, Inc., a biopharmaceutical company, from November 2014 until its acquisition by Gurnet Point Capital, LLC and Patient Square Capital in August 2022. Dr. Dere received a B.A. and an M.D. from the University of California, Davis.

Allene M. Diaz has served as a member of our Board of Directors since March 2021. Ms. Diaz has led AMD Consulting, a new product strategy and portfolio management consulting practice, since August 2020. She held the position of Senior Vice President of R&D Portfolio Management at GlaxoSmithKline from September 2019 to June 2020. From May 2015 to September 2019, she served as the Senior Vice President of Global Commercial Development and Program Strategy and as a member of the Executive Leadership Team at TESARO. Ms. Diaz has served on the board of directors of Ionis Pharmaceuticals, Inc., a biotechnology company, since June 2021. She previously served as a director of BCLS Acquisition Corp., a special purpose acquisition company, from October 2020 until November 2022, of Allena Pharmaceuticals, Inc., or Allena, a biopharmaceutical company, from April 2019 until September 2022, and of Erytech Pharma SA, a biopharmaceutical company, from September 2016 to September 2019. Ms. Diaz received a B.S. in psychology from Florida State University.

Andrew A. F. Hack, M.D., Ph.D., has served as a member of our Board of Directors since January 2017. Dr. Hack has served as a Managing Director of Bain Capital Life Sciences, a private equity fund that invests in biopharmaceutical, specialty pharmaceutical, medical device, diagnostics, and life science technology companies globally, since March 2019. Before joining Bain Capital, Dr. Hack was the Chief Financial Officer of Editas Medicine, Inc., a biotechnology company, from July 2015 through March 2019. Dr. Hack has served on the boards of directors of Dynavax Technologies Corp., a biopharmaceutical company, since August 2019 and of Nuvalent since April 2021. He previously served as a director of BCLS Acquisition Corp. from October 2020 until November 2022; of Allena from June 2018 to June 2021; and of Atea Pharmaceuticals, Inc., a biopharmaceutical company, from May 2020 to June 2021. Dr. Hack received an A.B. in biology with special honors, an M.D. and a Ph.D. in molecular genetics and cell biology from the University of Chicago.

Kristen Hege, M.D., has served as a member of our Board of Directors since August 2016. Dr. Hege recently retired as Senior Vice President, Early Clinical Development, Hematology/Oncology & Cell Therapy at Bristol Myers Squibb Company, or BMS, a global biopharmaceutical company, a position she held from November 2019, when BMS acquired Celgene Corporation, a pharmaceutical company, until March 2023. She joined Celgene Corporation in 2010 as Vice President, Translational Development. Dr. Hege has also held an active faculty position at the University of California, San Francisco Medical Center since 1996, most recently as Clinical Professor of Medicine, Hematology/Oncology, serving in that role as a volunteer since 2008. In February 2023, Dr. Hege was appointed to serve on the board of directors of Adaptimmune, effective as of November 1, 2023, and she has served on the board of directors of Graphite Bio, Inc., a biotechnology company, since April 2021. She also previously served as a director of Arcus Biosciences, Inc., a biopharmaceutical company, from October 2018 to November 2019. Dr. Hege received a B.A. in biochemistry summa cum laude from Dartmouth College and an M.D. from University of California, San Francisco.

Anna Protopapas has served as a member of our Board of Directors since March 2015 and she was our President and Chief Executive Officer from March 2015 until September 2023. Ms. Protopapas has served as chair of the board of directors of Nuvalent, Inc., or Nuvalent, a biotechnology company, since March 2022. She previously served as a director of Dicerna Pharmaceuticals, Inc., a biotechnology company, from January 2019 until June 2021. Ms. Protopapas received a B.S. in science and engineering from Princeton University, an M.S. in chemical engineering practice from the Massachusetts Institute of Technology and an M.B.A. from Stanford Graduate School of Business.

Martin Huber, M.D., has served as our President and Chief Executive Officer since September 2023 and as a member of our Board of Directors since April 2020. Prior to his current role, Dr. Huber served as President and Head of R&D of Xilio Therapeutics, Inc., or Xilio, a biotechnology company, from June 2022 until September 2023. He served as Xilio’s President of R&D from August 2021 to June 2022 and as Chief Medical Officer from April 2020 to June 2022. Prior to that, he served as Senior Vice President, Chief Medical Officer at TESARO from September 2015 to January 2019, and after TESARO’s acquisition by GlaxoSmithKline, he served as Senior Vice President, Clinical, from January 2019 to April 2020. Dr. Huber has served on the board of directors of Syndax Pharmaceuticals, Inc., a biotechnology company, since September 2021. Dr. Huber received a B.S. in biology from Texas Lutheran College and an M.D. from Baylor College of Medicine.