At Mersana, we all share a singular passion and vision: To dramatically improve the lives of people with cancer. We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun. 

If you share our passion to deliver an evolutionary leap in cancer patient care and our drive to tackle difficult challenges in a dynamic and collaborative environment, then please submit your resume or CV to


Principal/Senior Scientist, Analytical Chemistry - Platform Discovery

What’s in it for you?


In this role, you will have an opportunity to lead an analytical chemistry group focused on advancement of new ADC platform technologies and pipeline candidates. Specifically, the leader of this team will oversee the creation and development of novel analytics to characterize novel ADCs for Mersana and its partners.  Since we are on the cutting edge of a new therapeutic category with its own unique testing requirements, we will take your existing expertise in analytical development and protein characterization and complement it with our knowledge of polymer and small molecule chemistry.   We will work as a team to expand our knowledge base of our ADCs in order to enable their evolution towards optimized cancer therapies.  You will be immersed in a learning organization, with a need to bring an open mind and an interest in mastering this new therapeutic space at a rapid pace.  


As part of a growing company you will have the ability to hire and mentor staff and build processes that will drive innovation, teamwork and efficiency within the organization.  You and your team will represent Analytical Chemistry and work closely with teammates in Chemistry, Biology, and Bioconjugation on technology and pipeline teams to advance new technologies and ADCs towards lead candidate status.  Your team will also share their expertise with Analytical Chemistry colleagues who support CMC and DMPK in order to speed the manufacture of our ADCs and gain insight into their behavior in vivo.


View Full Description

Principal/Senior Scientist – Protein Characterization ADC - mAb

Mersana has an exciting new opportunity for a Senior/Principal Scientist working with our growing analytical chemistry team.

Key Responsibilities:

  • Responsible for protein analysis and protein characterization working with ADC technology.
  • Perform RP/IEX/SEC HPLC, LC/MS, CE/icIEF and spectrophotometrybased testing of antibodies and antibody-drug conjugates.
  • Perform HPLC and LC/MS analyses and routine maintenance on analytical instrumentation including Shimadzu and Agilent HPLC systems, ThermoFisher Q-Exactive LC MS/MS system.
  • Participate in the development/evaluation of new analytical methods to support our growing drug pipeline and assist our chemistry and bioconjugation groups with their sample preparation and analysis.
  • Development of high throughput methods for screening of antibodies and ADCs for various CQAs
  • Serve as an effective representative of Analytical Chemistry by clear communication, problem-solving and delivering on team goals as a member of Discovery pipeline and technology project teams
  • Schedule, implement method development and research activities; maintain accurate laboratory records and notebooks; follow analytical procedures and validation protocols in compliance with regulatory requirements and industry standards; write analytical reports and SOPs.
  • Develop and qualify new analytical methods for research materials evaluation.
View Full Description


Associate Director/Director, Antibody Engineering

The Associate Director/Director of Antibody Engineering will be the leader of antibody design and optimization for use in antibody-drug conjugates (ADCs) based on Mersana’s proprietary linker-payload technology. S/he will be work closely with the project teams to define screening cascades, identify lead mAbs, evaluate clinical developability, and optimize sequences; s/he will interface with CROs when needed. S/he will be the key strategist and thought leader on new antibody formats to complement new linker-payload platforms at Mersana. S/he will foster a culture of inclusion, engagement and collaboration in the project teams, the Biology group, and the entire organization.

View Full Description


Senior Scientist

What’s in it for you?


In this role, you will have an opportunity to contribute to the advancement of new ADC platform technologies, bioconjugation technologies, and pipeline candidates. Specifically, you will drive innovation and optimization related to the preparation, purification and characterization of novel ADCs for Mersana and its partners.  In this role, you will have the opportunity to initiate, direct and execute scientific research aimed at innovation and bioconjugation process improvements. Your expertise in working with protein conjugates will add value to our team, expanding our knowledge base of our ADCs and enable their timely progression towards breakthrough cancer therapies.  You will be immersed in a learning and team-focused environment, where demonstration of an open mind and interest in mastering this new therapeutic space, and close collaboration with fellow team members are keys to your success. 


As part of a growing company, you will have the ability to mentor junior staff.  You will represent Bioconjugation and work closely with teammates in Chemistry, Biology, and Analytical Chemistry, both internally and with collaboration partners, on technology and pipeline teams to advance new technologies and ADCs towards the clinic. 

View Full Description


Associate Director/Director, Business Development & Licensing

What’s in it for you?

In this role, you will have an opportunity to work closely with Mersana’s leadership and focus on the development and execution of the company’s corporate strategy.  You’ll assist in identifying strategic business opportunities including in-licensing agreements, partnerships, mergers, acquisitions, alliances and/or joint ventures, and then negotiate and review/write the agreements.  You’ll spend much of your time interacting with internal and external partners including outside counsel.  This role will have a great impact to Mersana at this extraordinary stage of the company’s development as you will also work closely with the executive team to support the IR and PR efforts. 

View Full Description


Director/Senior Director, Clinical Data Sciences

In this role you’ll be excited to build and lead the Clinical Data Sciences function.  This is a unique opportunity to bring your expertise in setting up first in human studies to international pivotal trials and your experience with filing NDAs, BLAs, etc.  You’ll form close partnerships with external CROs and other niche providers as well as internal stakeholders as you implement and set standards across drug development and platform-related development programs, implement GCP compliance, and build out a phase-appropriate internal clinical data handling department.  This position reports to Mersana’s VP, Clinical Operations.

  • You will have an opportunity to work in a broad cross functional capacity at Mersana and oversee multiple ongoing US and Global trials from Ph 1 to Ph 3.
  • This role will impact Mersana by establishing, maintaining, and growing the first clinical data function at Mersana.  
  • You will also have the opportunity to contribute/lead the development of a cutting edge IDMP and data warehouse.  Also, you will be a founding participant in the first BLA to be filed at Mersana.
  • To be successful, you will have previously worked as a daily data manager and successfully work on (or preferably been an SME lead) an IT implementation team for a clinical data handling system.

If you’d like to build out a clinical data sciences team that supports broad cross-function drug development teams at Mersana, this is an ideal job. We seek a person who is efficient and goal-focused, intent on creatively and compliantly maximizing system interfaces that leverage both internal and partner’s systems.  If you want to work with a top-notch IT team, seasoned Clinical Research and Preclinical colleagues who still love their work and stay current on all cutting-edge sciences, and a Research organization that is a leader in the industry,  join the Mersana team.

View Full Description


Head, Discovery Chemistry

Leading by example, s/he will inspire with innovative scientific vision and thought-leadership, promote productive collaboration, and motivate and challenge the research organization to accomplish ambitious goals. S/he will provide thoughtful mentorship and management to a high-caliber research and development team. S/he will be accountable for leading the discovery chemistry team to execute on the pipeline programs and to bring on new discovery programs.

View Full Description